Mass-Spectrometric Approaches for DNA-Based Genetic Screening
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چکیده
منابع مشابه
Mass-spectrometric approaches for DNA-based genetic screening.
In the current issue of Clinical Chemistry, Braun et al. [1] describe a mutational analysis method that combines primer oligo base extension (PROBE) and matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF-MS). This application further extends the use of MS for genetic analysis and suggests a possible role in the clinic. However, what is the long-term potentia...
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Ferrous ion and 2-oxoglutarate (2OG) oxygenases catalyze the demethylation of N(epsilon)-methylated lysine residues in histones. Here we report studies on the inhibition of the JMJD2 subfamily of histone demethylases, employing binding analyses by nondenaturing mass spectrometry (MS), dynamic combinatorial chemistry coupled to MS, turnover assays, and crystallography. The results of initial bin...
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available from a number of commercial suppliers and Cambridge, Massachusetts 02142 include compounds from historical archives, natural sources, or those produced using combinatorial chemistry. Typically, purveyors will supply compounds in 96-Chemical genetics is an emerging technology for re-or 384-well plates and provide structure data (SD) files vealing the signaling networks that regulate bi...
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ژورنال
عنوان ژورنال: Clinical Chemistry
سال: 1997
ISSN: 0009-9147,1530-8561
DOI: 10.1093/clinchem/43.7.1108